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AutoSoft Systems |
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AutoSoft
Systems |
2 Round Hill
Court |
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East Greenwich,
RI 02818 |
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401.885.3631 |
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401.884.5653 Fax |
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401.996.3631 Cell |
| AMDG |
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Decision Ready
Information! |
autosoft@aol.com |
| Commercial & custom multi-user computer software for a
variety of applications including performance metrics, statistical analysis,
data extraction and merger from multiple large databases, computer simulation
and management information systems.
Founded in 1982. |
| We know Excel! Whenever possible, Excel
is the user interface, VBA is the programming language, ODBC connects to the
database of your choice. |
| Home |
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& Cable |
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& Biotech |
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AMDG |
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| Dr. Serdakowski has been working with the BioProcess Institute
since its inception in 2007. |
| Click Here to view
The BioProcess Institute's Web Site |
| The following is a summary of some of the programs developed
over the years. |
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High Purity
Water Trending |
High purity water production is critical to the
successful production of pharmaceuticals.
Stainless steel pipes build up "rouge" on their interior
surfaces with time as the high purity water leeches the trace metals from the
stainless steel. This rouge can reach
a critical level and these elements can start to appear in the water stream
in elevated levels. Additionally,
water purification treatments can begin to fail and also allow elevated
concentrations. These effects can be
quite gradual, and at the part per billion level, difficult to separate out
the "signal to noise". This
tool can spot very subtle trends in the trace elements, and help predict when
the expensive "derouging" process is required. This tool also allows the user to compare
the performance of different water systems.
The tool currently has over 22,000 data points, providing a large data
set to allow for relative performance measurements. |
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Clean Room Air Quality Trending |
Akin to the High Purity Water Trending program
described above, Clean Room Air Quality needs to be closely monitored. This tool takes mountains of raw data and
generates "Decision Ready Information". |
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AutoDNA |
Biopharmaceutical production requires cell
banks that are stable over many years.
One confirms that the cells' DNA is stable through periodic
sampling. Confirming that a cell bank
is stable over several years is a bit tricky as standards change. Also, the DNA of a cell is not
characterized by a single point, but by a series of points on multiple lanes
of a DNA ladder. Proper definition of
a standard could require 5O+ different data points on multiple lanes. Analysis of a sample again is over multiple
lanes and 50+ data points. Significant
statistics need to be applied to confirm the cell bank is stable, or to
identify that the cell bank is changing with time. |
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AutoInquiry |
From GE Proficy's web site: "Proficy
Historian is a powerful enterprise-wide data historian that collects,
archives, and distributes tremendous volumes of production information at
extremely high speeds." Proficy
does this very well, but getting to this data once it has been recorded, can
be quite a problem. AutoInquiry
provides a very simple interface to extract this information from GE Proficy
and output it directly to Excel, as well a create a graph of the
results. AutoInquiry as a very quick
learning curve and users are up and running in minutes. |
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AutoTrender |
The BioProcess Institute performs a number of
tests for a number of clients. One
test required multiple SIP (Steam In Place) of gaskets so that their
resistance to deformity could be quantified.
Sometimes these tests many take weeks or months with
"mountains" of data accumulating in the GE Proficy Historian
database. AutoTrender is
AutoInquiry's "Big Brother".
AutoTrender builds on the simple AutoInquiry extraction and performs
detailed calculations to solve this very specific problem. |
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Process
Systems Cleaning Analysis |
Periodic cleaning of piping systems is required
at any Bioprocess facility. One has to
assure that the cleaning solution reach all surfaces, including "dead
legs" resulting from closed valves.
This dead legs can be different orientations, point up, down or
sideways. The BioProcess Institute was
commissioned to perform an extensive battery of tests on a variety of pipe
diameter and dead leg orientations to determine the velocity of fluid
required in order to wet out all surfaces in the dead legs. Once the thousands of data points were
collected, AutoSoft worked with the BioProcess Institute to identify
recommendations for minimum flow rates for various geometries. |
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AutoAlarms |
The BioProcess Institute often conducts
automated testing 24x7 for weeks or months at a time. The testing process has a very customized
and sophisticated control system to meet the exact nature of the test at
hand. The AutoAlarms utility runs in
the background on the process control machine and constantly checks for any
process deviation. If a deviation is
identified, AutoAlarms then send emails and text messages to BioProcess
Institute personnel that a deviation exists. |
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Gasket
Intrusion Analysis |
It is essential that a gasket-clamp combination
provide a leak-free connection. Of
equal importance is that the inner diameter of the gasket-clamp combination
identically match the inner diameter of the piping system. Any bulging or recess of the gasket
provides a "dead space" in the flow stream where unwanted debris
could accumulate and provide a source of contamination or a home for
bacteria. The BioProcess Institute
offers a series of reports on the performance of various gasket-clamp
combinations. This software tool takes
the large amount of raw data accumulated by BioProcess Institute technicians
and allows BioProcess Engineers to visualize results, draw conclusions and
provide summary reports to clients. |
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Steam In Place
Analysis |
Gaskets and diaphragm valves will eventually
fail if left in a process stream.
Changing them before they are worn out is a waste of time and
money. Leaving them in beyond the failure
point will be catastrophic. The BioProcess Institute studies this problem and
recommends duty cycles for a myriad of gaskets and diaphragms. In order to make these assessments, a vast
amount of testing has to be performed.
This software tool takes the large amount of raw data accumulated by
BioProcess Institute technicians and allows BioProcess Engineers to visualize
results, draw conclusions and provide summary reports to clients. |
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| AutoSoft Systems | 2 Round Hill Court, East
Greenwich, Rhode Island, USA 02818 | 401.885.3631 | Fax: 401.884.5653 |
Mobile: 401.996.3631 |
| This web page was last updated at 04/08/2015 09:08 AM and is
written in EXCEL! |
| AXIOM is a Trademark of Consona - USYS is a Trademark of Zumbach
- AutoSoft Systems is not affiliated with Consona nor Zumbach |
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